Curcio-Vonlanthen V Schneider CH Frutig K Blaser K Kalbacher H 1997 Based on immunogenicity studies, two T-cell epitopes in melittin were found to be functional in guinea pigs, one being centrally located, the other one residing in the C-terminal chain. In Balb/c mice only the central epitope was found to be active. A human T-cell clone was found by T-cell proliferation studies to employ strictly the C-terminal chain. Truncation of melittin peptides at the N-terminus did not markedly affect the capacity of guinea pigs to develop anti-IgG responses towards peptidic epitopes and towards a C-terminally attached haptenic group. Attachment of various substituents inside and outside the T-cell epitopic areas had no marked effect on antibody responses. In contrast, the substituents positioned within a T-cell epitope abolished T-cell proliferation. This difference between whole animal data and cellular in vitro responses is presently not understood. https://sonar.ch/global/documents/32764 eng info:eu-repo/semantics/altIdentifier/doi/10.1002/(sici)1099-1387(199707)3:4<267::aid-psc106>3.0.co;2-7 info:eu-repo/semantics/altIdentifier/pmid/9262645 Journal of peptide science : an official publication of the European Peptide Society. - 1997 Amino Acid Sequence Animals Cell Division Cell Line Clone Cells Epitopes, T-Lymphocyte Guinea Pigs Humans Melitten Mice Mice, Inbred BALB C Molecular Sequence Data T-Lymphocytes Molecular parameters in melittin immunogenicity. http://purl.org/coar/resource_type/c_6501