<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Grouzmann E</dc:creator>
  <dc:creator>Cressier F</dc:creator>
  <dc:creator>Walker P</dc:creator>
  <dc:creator>Hofbauer K</dc:creator>
  <dc:creator>Waeber B</dc:creator>
  <dc:creator>Brunner HR</dc:creator>
  <dc:date>1994</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">The present data show that monoclonal antibodies (NPY02, NPY03, NPY04, NPY05) directed against 4 distinct epitopes on NPY may have different actions on NPY binding and NPY-induced cellular responses. NPY02 and NPY05 recognize the 11-24 and 32-36 amidated form of NPY, respectively. These 2 antibodies block the binding of NPY to its receptor as well as the NPY-induced inhibition of cAMP accumulation caused in SK-N-MC cells by forskolin. NPY02 and NPY05 have also an inhibitory action on NPY-induced contraction of rabbit femoral arteries. NPY03 and NPY04 are directed against the 27-34 and 1-12 part of NPY, respectively. NPY03 and NPY04 inhibit the binding of NPY only at very high concentrations and have a weak effect on cAMP response to NPY. NPY02 and NPY05 might provide useful tools to study the effect of NPY in cellular systems and organ preparations.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/35312</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/0167-0115(94)90541-x</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/7716277</dc:relation>
  <dc:source>Regulatory peptides. - 1994</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Amino Acid Sequence</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Antibodies, Monoclonal</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Cyclic AMP</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Epitope Mapping</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Immunologic Techniques</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">In Vitro Techniques</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Molecular Sequence Data</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Neuropeptide Y</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Radioligand Assay</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Receptors, Neuropeptide Y</dc:subject>
  <dc:title xmlns:ns12="xml" ns12:lang="en">Interactions between NPY and its receptor: assessment using ant-NPY antibodies.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>