Nuciforo S Heim MH 2021 The organoid model represents a major breakthrough in cell biology that has revolutionised biomedical research. Organoids are 3D physiological in vitro structures that recapitulate morphological and functional features of in vivo tissues and offer significant advantages over traditional cell culture methods. Liver organoids are of particular interest because of the pleiotropy of functions exerted by the human liver, their utility to model different liver diseases, and their potential application as cell-based therapies in regenerative medicine. Moreover, because they can be derived from patient tissues, organoid models offer new perspectives in personalised medicine and drug discovery. In this review, we discuss the current liver organoid models for the study of liver disease. application/pdf https://sonar.ch/global/documents/35406 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jhepr.2020.100198 info:eu-repo/semantics/altIdentifier/pmid/33241206 info:eu-repo/semantics/openAccess JHEP reports : innovation in hepatology. - 2021 3D cultures A1AT, alpha-1 antitrypsin ALD, alcohol-related liver disease CCA, cholangiocarcinoma CFTR, cystic fibrosis transmembrane conductance regulator CHC, combined hepato-cholangiocarcinoma CLD, chronic liver disease CTLN1, citrullinemia type 1 Chol-orgs, cholangiocyte organoids Disease modelling EGF, epidermal growth factor ER, endoplasmic reticulum ESCs, embryonic stem cells FFAs, free fatty acids HCC, hepatocellular carcinoma HUVEC, human umbilical vein endothelial cells Hep-orgs, hepatocyte organoids IL-, interleukin- Liver disease MSC, mesenchymal stem cell NAFLD, non-alcoholic fatty liver disease Organoids PDO, patient-derived organoid PDX, patient-derived xenograft PHH, primary human hepatocyte PSC, primary sclerosing cholangitis Personalised medicine Preclinical models iPSC, induced pluripotent stem cell Organoids to model liver disease. http://purl.org/coar/resource_type/c_6501