<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Jessberger S</dc:creator>
  <dc:creator>Parent JM</dc:creator>
  <dc:date>2015</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Seizure activity in the hippocampal region strongly affects stem cell-associated plasticity in the adult dentate gyrus. Here, we describe how seizures in rodent models of mesial temporal lobe epilepsy (mTLE) affect multiple steps in the developmental course from the dividing neural stem cell to the migrating and integrating newborn neuron. Furthermore, we discuss recent evidence indicating either that seizure-induced aberrant neurogenesis may contribute to the epileptic disease process or that altered neurogenesis after seizures may represent an attempt of the injured brain to repair itself. Last, we describe how dysfunction of adult neurogenesis caused by chronic seizures may play an important role in the cognitive comorbidities associated with mTLE.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/35685</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1101/cshperspect.a020677</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/26552418</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Cold Spring Harbor perspectives in biology. - 2015</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Cell Movement</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Cell Proliferation</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Epilepsy, Temporal Lobe</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Hippocampus</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Models, Biological</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Neural Stem Cells</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Neurogenesis</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Rats</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Seizures</dc:subject>
  <dc:title xmlns:ns12="xml" ns12:lang="en">Epilepsy and Adult Neurogenesis.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>