<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Gaisl T</dc:creator>
  <dc:creator>Wons AM</dc:creator>
  <dc:creator>Rossi V</dc:creator>
  <dc:creator>Bratton DJ</dc:creator>
  <dc:creator>Schlatzer C</dc:creator>
  <dc:creator>Schwarz EI</dc:creator>
  <dc:creator>Camen G</dc:creator>
  <dc:creator>Kohler M</dc:creator>
  <dc:date>2016</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">BACKGROUND
A high P-wave duration and dispersion (Pd) have been reported to be a prognostic factor for the occurrence of paroxysmal atrial fibrillation (PAF), a condition linked to obstructive sleep apnea (OSA). We tested the hypothesis of whether a short-term increase of P-wave duration and Pd can be induced by respiratory manoeuvres simulating OSA in healthy subjects and in patients with PAF.


METHODS
12-lead-electrocardiography (ECG) was recorded continuously in 24 healthy subjects and 33 patients with PAF, while simulating obstructive apnea (Mueller manoeuvre, MM), obstructive hypopnea (inspiration through a threshold load, ITH), central apnea (AP), and during normal breathing (BL) in randomized order. The P-wave duration and Pd was calculated by using dedicated software for ECG-analysis.


RESULTS
P-wave duration and Pd significantly increased during MM and ITH compared to BL in all subjects (+13.1 ms and +13.8 ms during MM; +11.7 ms and +12.9 ms during ITH; p&lt;0.001 for all comparisons). In MM, the increase was larger in healthy subjects when compared to patients with PAF (p&lt;0.05).


CONCLUSION
Intrathoracic pressure swings through simulated obstructive sleep apnea increase P-wave duration and Pd in healthy subjects and in patients with PAF. Our findings imply that intrathoracic pressure swings prolong the intra-atrial and inter-atrial conduction time and therefore may represent an independent trigger factor for the development for PAF.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/35866</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0152994</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/27071039</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>PloS one. - 2016</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Adolescent</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Adult</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Aged</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Atrial Fibrillation</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Case-Control Studies</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Electrocardiography</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Female</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Heart Rate</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Male</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Middle Aged</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Models, Biological</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Pressure</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Risk Factors</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Sleep Apnea, Central</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Sleep Apnea, Obstructive</dc:subject>
  <dc:subject xmlns:ns17="xml" ns17:lang="en">Young Adult</dc:subject>
  <dc:title xmlns:ns18="xml" ns18:lang="en">Simulated Obstructive Sleep Apnea Increases P-Wave Duration and P-Wave Dispersion.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>