Zagalak B Neuheiser F Redweik U Bosshard R Leimbacher W 1988 The first chemical synthesis of D-neopterin-3'-triphosphate and D-7,8-dihydroneopterin-3'-triphosphate is described. D-neopterin-3'-monophosphate was first 1'-2'-0-formylated with anhydrous formic acid, then activated with 1,1'-carbonyldiimidazole and phosphorylated with n-tributyl-ammonium pyrophosphate. The yield of 3'-NTP was 24%. D-7,8-dihydroneopterin-3'-triphosphate was obtained by chemical (hyposulfite) or catalytic (Pd:H2) reduction of 3'-NTP. Preparations from both reductions were fully active in two different enzymatic systems: synthesis of L-5,6,7,8-tetrahydrobiopterin and in the C-2'-epimerization reaction to L-7,8-dihydromonapterin-3'-triphosphate. https://sonar.ch/global/documents/36090 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/s0006-291x(88)80411-x info:eu-repo/semantics/altIdentifier/pmid/3377772 Biochemical and biophysical research communications. - 1988 Biopterin Methods Neopterin Pteridines Synthesis of enzymatically active D-7,8-dihydroneopterin-3'-triphosphate. http://purl.org/coar/resource_type/c_6501