<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Ody C</dc:creator>
  <dc:creator>Jungblut-Ruault S</dc:creator>
  <dc:creator>Cossali D</dc:creator>
  <dc:creator>Barnet M</dc:creator>
  <dc:creator>Aurrand-Lions M</dc:creator>
  <dc:creator>Imhof BA</dc:creator>
  <dc:creator>Matthes T</dc:creator>
  <dc:date>2007</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Differentiation of naïve B cells into plasma cells or memory cells occurs in the germinal centers (GCs) of lymph follicles or alternatively via a GC- and T-cell-independent pathway. It is currently assumed that B-cell lymphomas correlate to normal B-cell differentiation stages, but the precise correlation of several B-cell lymphomas to these two pathways remains controversial. In the present report, we describe the junctional adhesion molecule C (JAM-C), currently identified at the cell-cell border of endothelial cells, as a new B-cell marker with a tightly regulated expression during B-cell differentiation. Expression of JAM-C in tonsils allows distinction between two CD27+ B-cell subpopulations: JAM-C- GC B cells and JAM-C+ non-germinal B cells. The expression of JAM-C in different B-cell lymphomas reveals a disease-specific pattern and allows a clear distinction between JAM-C- lymphoproliferative syndromes (chronic lymphocytic leukemia, mantle cell lymphoma and follicular lymphoma) and JAM-C+ ones (hairy cell leukemia, marginal zone B-cell lymphoma). Therefore, we propose JAM-C as a new identification tool in B-cell lymphoma diagnosis.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/38704</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1038/sj.leu.2404689</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/17429428</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Leukemia. - 2007</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">B-Lymphocytes</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Biomarkers, Tumor</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Cell Adhesion Molecules</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Germinal Center</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Leukemia, B-Cell</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Lymphoma, B-Cell</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Tumor Necrosis Factor Receptor Superfamily, Member 7</dc:subject>
  <dc:title xmlns:ns9="xml" ns9:lang="en">Junctional adhesion molecule C (JAM-C) distinguishes CD27+ germinal center B lymphocytes from non-germinal center cells and constitutes a new diagnostic tool for B-cell malignancies.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>