<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Izui S</dc:creator>
  <dc:date>1994</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Autoimmune hemolytic anemia (AHA) is characterized by the production of Coombs' antibodies, which are responsible for the destruction of red blood cells (RBCs). Analysis of both monoclonal anti-RBC autoantibodies derived from autoimmune New Zealand black mice and transgenic mice expressing a pathogenic IgM anti-RBC autoantibody has considerably improved our understanding of the B-cell responses involved in AHA, although our knowledge of T-cell immunity in AHA is still limited. The identification of the major T-cell epitope in the context of MHC class II molecules would be of paramount importance in helping to elucidate the cellular and molecular basis central to the development of AHA.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/38999</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/0952-7915(94)90015-9</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/7710716</dc:relation>
  <dc:source>Current opinion in immunology. - 1994</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Anemia, Hemolytic, Autoimmune</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Autoantibodies</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Autoantigens</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Erythrocytes</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Immunoglobulin M</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Mice</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Mice, Inbred NZB</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Mice, Transgenic</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">T-Lymphocytes</dc:subject>
  <dc:title xmlns:ns12="xml" ns12:lang="en">Autoimmune hemolytic anemia.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>
