<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Federau C</dc:creator>
  <dc:creator>O'Brien K</dc:creator>
  <dc:creator>Meuli R</dc:creator>
  <dc:creator>Hagmann P</dc:creator>
  <dc:creator>Maeder P</dc:creator>
  <dc:date>2014</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">PURPOSE
To evaluate the feasibility of intravoxel incoherent motion (IVIM) perfusion measurements in the brain with currently available imaging systems.


MATERIALS AND METHODS
We acquired high in-plane resolution (1.2×1.2 mm2) diffusion-weighted images with 16 different values of b ranging from 0 to 900 s/mm2, in three orthogonal directions, on 3T systems with a 32-multichannel receiver head coil. IVIM perfusion maps were extracted by fitting a double exponential model of signal amplitude decay. Regions of interest were drawn in pathological and control regions, where IVIM perfusion parameters were compared to the corresponding dynamic susceptibility contrast (DSC) parameters.


RESULTS
Hyperperfusion was found in the nonnecrotic or cystic part of two histologically proven glioblastoma multiforme and in two histologically proven glioma WHO grade III, as well as in a brain metastasis of lung adenocarcinoma, in a large meningioma, and in a case of ictal hyperperfusion. A monoexponential decay was found in a territory of acute ischemia, as well as in the necrotic part of a glioblastoma. The IVIM perfusion fraction f correlated well with DSC CBV.


CONCLUSION
Our initial report suggests that high-resolution brain perfusion imaging is feasible with IVIM in the current clinical setting.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/42669</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1002/jmri.24195</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/24068649</dc:relation>
  <dc:source>Journal of magnetic resonance imaging : JMRI. - 2014</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">brain</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">diffusion</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">intravoxel incoherent motion (IVIM)</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">perfusion</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Adolescent</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Adult</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Brain Neoplasms</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Contrast Media</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Diffusion Magnetic Resonance Imaging</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Encephalitis</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Feasibility Studies</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Female</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Glioma</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Male</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Middle Aged</dc:subject>
  <dc:subject xmlns:ns17="xml" ns17:lang="en">Perfusion</dc:subject>
  <dc:subject xmlns:ns18="xml" ns18:lang="en">Sampling Studies</dc:subject>
  <dc:subject xmlns:ns19="xml" ns19:lang="en">Sensitivity and Specificity</dc:subject>
  <dc:subject xmlns:ns20="xml" ns20:lang="en">Stroke</dc:subject>
  <dc:subject xmlns:ns21="xml" ns21:lang="en">Young Adult</dc:subject>
  <dc:title xmlns:ns22="xml" ns22:lang="en">Measuring brain perfusion with intravoxel incoherent motion (IVIM): initial clinical experience.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>