Brel O Touré S Levasseur M Lechat C Pellissier L Wolfender JL Van-Elslande E Litaudon M Dusfour I Stien D Eparvier V 2020 Fifty-seven entomopathogenic microorganisms were screened against human pathogens and subjected to mass spectrometry molecular networking based dereplication. Isaria farinosa BSNB-1250, shown to produce potentially novel biologically active metabolites, was grown on a large scale on potato dextrose agar, and paecilosetin (1) and five new analogues (2-6) were subsequently isolated. The structures of the new compounds were elucidated using 1D and 2D NMR. The absolute configurations of compounds 1-6 were determined using Mosher ester derivatives (1, 3, 4), comparison of experimental and calculated ECD spectra (2-4 and 6), and single-crystal X-ray diffraction analysis (5). Compounds 1 and 5 exhibited strong antibacterial activity against MSSA and MRSA with MIC values of 1-2 μg/mL. https://sonar.ch/global/documents/42701 eng info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.jnatprod.0c00444 info:eu-repo/semantics/altIdentifier/pmid/33021377 Journal of natural products. - 2020 Organic Chemistry Complementary and alternative medicine Analytical Chemistry Molecular Medicine Pharmacology Drug Discovery Pharmaceutical Science Paecilosetin Derivatives as Potent Antimicrobial Agents from Isaria farinosa. http://purl.org/coar/resource_type/c_6501