Fluss J Garcia-Tarodo S Granier M Villega F Ferey S Husson B Kossorotoff M Muehlethaler V Lebon S Chabrier S 2016 BACKGROUND The aetiology of perinatal arterial ischemic stroke remains speculative. It is however widely accepted that the aetiology is multifactorial, involving various maternal, placental, foetal and neonatal risk factors. A resulting thromboembolic process is hypothesized and the placenta identified as the most plausible source. An arteriopathy, as observed in a significant proportion of childhood ischemic stroke, is thought to be rare. METHODS We report here five cases of perinatal stroke that differ from the vast majority by documented carotid occlusion, and add eleven other similar cases from the literature. RESULTS In the majority, an intraluminal thrombus of placental origin is the most probable hypothesis, while in the remaining ones, one can reasonably presume a direct vessel wall injury related to a traumatic delivery, yet generally unproven by imaging. CONCLUSION We hypothesize that most of these cases share similar pathophysiology with the more common perinatal arterial ischemic stroke but differ by a persistent identified thrombus in the carotid artery at the time of first imaging, leading to a more severe and extended ischemic damage responsible for an adverse neurological outcome. https://sonar.ch/global/documents/46350 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejpn.2016.03.003 info:eu-repo/semantics/altIdentifier/pmid/27025300 European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. - 2016 Carotid occlusion Dissection Neonatal arterial ischemic stroke Perinatal stroke Placental thromboembolism Arterial Occlusive Diseases Brain Brain Ischemia Carotid Arteries Carotid Artery Diseases Cerebral Angiography Cerebral Palsy Developmental Disabilities Epilepsies, Partial Female Humans Infant, Newborn Intellectual Disability Magnetic Resonance Angiography Male Placenta Pregnancy Risk Factors Stroke Perinatal arterial ischemic stroke related to carotid artery occlusion. http://purl.org/coar/resource_type/c_6501