<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Eberhard M</dc:creator>
  <dc:creator>Erne P</dc:creator>
  <dc:date>1995</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Inositol 1,4,5-trisphosphate (IP3)-induced release of Ca2+, its regulation by IP3 and Ca2+, and the metabolism of IP3 was analyzed in saponin-permeabilized human platelets. At 37 degrees C successive sub-maximal aliquots of IP3 induce a biphasic release of part of the IP3-sensitive Ca2+ pool each time. Although the IP3-induced Ca2+ flux rapidly ceases after addition of IP3, the IP3-sensitive Ca2+ stores regain their sensitivity shortly after stimulation with IP3. Under these conditions IP3 is rapidly hydrolyzed to inositol 1,4-bisphosphate which is unable to release Ca2+. The cooperativity of IP3-induced Ca2+ release and the metabolism of IP3 can account for both the rapid recovery of sensitivity of the IP3-sensitive Ca2+ pool and the partial release induced by sub-maximal concentrations of IP3. The data of the present study favour a steady state rather than an all-or-none mechanism of Ca2+ release.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/4640</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.3109/10799899509045222</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/8903946</dc:relation>
  <dc:source>Journal of receptor and signal transduction research. - 1995</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Aniline Compounds</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Blood Platelets</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Calcium</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Fluorescent Dyes</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Hydrolysis</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">In Vitro Techniques</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Inositol 1,4,5-Trisphosphate</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Inositol Phosphates</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Kinetics</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Signal Transduction</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Xanthenes</dc:subject>
  <dc:title xmlns:ns13="xml" ns13:lang="en">Regulation of inositol 1,4,5-trisphosphate-induced calcium release by inositol 1,4,5-trisphosphate and calcium in human platelets.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>