<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Demaurex N</dc:creator>
  <dc:creator>Saul S</dc:creator>
  <dc:date>2018</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Stromal interaction molecule (STIM) proteins regulate store-operated Ca2+ entry (SOCE) in innate and adaptive immune cells and participate in the Ca2+ signals that control the functions of neutrophils, the first line of host defence against bacterial and fungal infections. Loss-of-function experiments in animal and cellular models indicate that both STIM1 and STIM2 regulate neutrophil functions, but the complexity of the SOCE machinery and the versatility of neutrophils complicate the evaluation of the results. This review aims to summarize the latest progress in the field, with special attention to the details of the experimental designs. Future study design should aim to improve the standardization of experimental procedures and to provide a more holistic understanding of the role of STIM proteins in neutrophils function.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/46520</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1113/JP275639</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/29441588</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>The Journal of physiology. - 2018</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">NADPH oxidase</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">animal models</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">calcium signalling</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">ion channels</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">phagocytosis</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">store-operated Ca2+ entry</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Calcium Signaling</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Neoplasm Proteins</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Neutrophils</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Stromal Interaction Molecule 1</dc:subject>
  <dc:title xmlns:ns12="xml" ns12:lang="en">The role of STIM proteins in neutrophil functions.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>