Leone DP Genoud S Atanasoski S Grausenburger R Berger P Metzger D Macklin WB Chambon P Suter U 2003 Inducible transgenesis provides a valuable technique for the analysis of gene function in vivo. We report the generation and characterization of mouse lines carrying glia lineage-specific transgenes expressing an improved variant of the tamoxifen-inducible Cre recombinase, CreERT2, where the recombinase is fused to a mutated ligand binding domain of the human estrogen receptor. Using a PLP-CreERT2 transgene, we have generated mice that show specific inducible Cre function, as analyzed by cross-breeding experiments into the Rosa26 Cre-LacZ reporter line, in developing and adult Schwann cells, in mature myelinating oligodendrocytes, and in undifferentiated NG2-positive oligodendrocyte precursors in the adult. Using a P0Cx-CreERT2 transgene, we have also established mouse lines with inducible Cre function specifically in the Schwann cell lineage. These tamoxifen-inducible CreERT2 lines will allow detailed spatiotemporally controlled analysis of gene functions in loxP-based conditional mutant mice in both developing and adult Schwann cells and in the oligodendrocyte lineage. https://sonar.ch/global/documents/47091 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/s1044-7431(03)00029-0 info:eu-repo/semantics/altIdentifier/pmid/12727441 Molecular and cellular neurosciences. - 2003 Animals Animals, Newborn Brain Cell Lineage Dose-Response Relationship, Drug Female Fetus Gene Expression Regulation Genes, Reporter Integrases Lactation Male Mice Mice, Transgenic Mutagenesis Oligodendroglia Peripheral Nervous System Protein Structure, Tertiary Receptors, Estrogen Recombinant Fusion Proteins Schwann Cells Stem Cells Tamoxifen Transgenes Viral Proteins Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells. http://purl.org/coar/resource_type/c_6501