<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Woycechowsky KJ</dc:creator>
  <dc:creator>Hilvert D</dc:creator>
  <dc:date>2004</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">The efficient engineering of enzymes with novel activities remains an ongoing challenge. Towards this end, genetic selection techniques provide a method for finding rare solutions to catalytic problems that requires only a limited foreknowledge of structure-function relationships. We have used genetic selections to extensively probe the structure and mechanism of chorismate mutases. The insights gained from these investigations will aid future enzyme design efforts.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/47139</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1432-1033.2004.04073.x</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/15096202</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>European journal of biochemistry. - 2004</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Binding Sites</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Catalysis</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Chorismate Mutase</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Protein Engineering</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Protein Folding</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Protein Structure, Secondary</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Selection, Genetic</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Structure-Activity Relationship</dc:subject>
  <dc:title xmlns:ns9="xml" ns9:lang="en">Deciphering enzymes. Genetic selection as a probe of structure and mechanism.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>