Fierstra J van Niftrik C Piccirelli M Bozinov O Pangalu A Krayenbühl N Valavanis A Weller M Regli L 2018 PURPOSE Cerebral diffuse gliomas exhibit perilesional impaired cerebrovascular reactivity (CVR), yet the degree of impairment as well as its full spatial extent in the brain remains unknown. With quantitative fMRI, we studied twelve subjects with untreated brain diffuse glioma and twelve healthy controls to assess CVR impairment and determine its distribution throughout the brain. METHODS In a prospective case-control study, quantitative CVR measurements were derived from BOLD fMRI volumes during standardized iso-oxic changes in carbon dioxide. Whole brain CVR was assessed with additional detailed analyses using specific tumor and tissue masks and compared to datasets of healthy controls. RESULTS Whole brain CVR was significantly impaired compared to healthy controls (0.11±0.10 versus 0.28±0.8, p<0.01). All diffuse glioma patients exhibited even more severely impaired intralesional CVR (mean 0.01±0.06). Increasing tumor volume significantly correlated with severity of intralesional CVR impairment (p<0.05, R2=0.38), and whole brain CVR impairment (p<0.05, R2=0.55). CONCLUSION Patients with brain diffuse glioma exhibit intralesional and whole brain impaired CVR with severity correlating to tumor volume. Quantitative fMRI may be entertained to study antitumor therapy efficacy by tracking CVR changes and may have a complementary role to better interpret BOLD associated neurovascular uncoupling. application/pdf https://sonar.ch/global/documents/47364 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mri.2017.09.017 info:eu-repo/semantics/altIdentifier/pmid/28986176 info:eu-repo/semantics/openAccess Magnetic resonance imaging. - 2018 BOLD Carbon dioxide Cerebrovascular reactivity Diffuse glioma fMRI Adult Aged Aged, 80 and over Brain Brain Mapping Brain Neoplasms Case-Control Studies Cerebrovascular Circulation Female Glioma Humans Magnetic Resonance Imaging Male Middle Aged Prospective Studies Diffuse gliomas exhibit whole brain impaired cerebrovascular reactivity. http://purl.org/coar/resource_type/c_6501