<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Hönger G</dc:creator>
  <dc:creator>Mayr M</dc:creator>
  <dc:creator>Dickenmann M</dc:creator>
  <dc:creator>Mihatsch MJ</dc:creator>
  <dc:creator>Schaub S</dc:creator>
  <dc:date>2008</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">BACKGROUND
C4d-staining in peritubular capillaries (PTC) in allograft biopsies is a hallmark of antibody-mediated rejection (AMR). This study investigated whether urinary C4d correlates with C4d-staining in PTC, allowing for a noninvasive screening procedure.


METHODS
Urine samples from 34 patients with diffuse C4d-staining in PTC (C4d-pos group) and 68 urine samples from patients with negative C4d-staining in PTC (C4d-negative group) matched 1:2 according to proteinuria and time posttransplant were compared regarding urinary C4d-levels.


RESULTS
Overall, urinary C4d/creatinine-ratios (C4d/C) were not different between the C4d-positive and the C4d-negative group (P=0.55). Urinary C4d/C strongly correlated with total protein/creatinine-ratios (P/C) (r2=0.53; P&lt;0.0001) and albumin/creatinine-ratios (r2=0.52; P&lt;0.0001). C4d/C were not different between C4d-pos and C4d-negative patients with P/C&gt;50 mg/mmol (P=0.57) and P/C&lt;50 mg/mmol (P=0.65), respectively. However, in both the C4d-positive and the C4d-negative group urinary C4d/C were significantly higher in patients with P/C&gt;50 mg/mmol than in patients with P/C&lt;50 mg/mmol (P&lt;or=0.005). Furthermore, longitudinal analysis in 3 patients with distinct clinico-pathological courses demonstrated that urinary C4d/C closely followed P/C regardless of C4d-staining in PTC.


CONCLUSION
Urinary C4d does not correlate with C4d-staining in PTC but reflects nonspecific glomerular injury. Therefore, urinary C4d is likely not a useful biomarker for non-invasive screening and monitoring of AMR.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/4815</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1097/TP.0b013e3181641d8c</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/18347532</dc:relation>
  <dc:source>Transplantation. - 2008</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Adolescent</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Adult</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Aged</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Capillaries</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Complement C4b</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Creatinine</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Female</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Follow-Up Studies</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Graft Rejection</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Kidney Glomerulus</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Kidney Transplantation</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Kidney Tubules</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Male</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Middle Aged</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Peptide Fragments</dc:subject>
  <dc:subject xmlns:ns17="xml" ns17:lang="en">Postoperative Complications</dc:subject>
  <dc:subject xmlns:ns18="xml" ns18:lang="en">Time Factors</dc:subject>
  <dc:subject xmlns:ns19="xml" ns19:lang="en">Transplantation, Homologous</dc:subject>
  <dc:title xmlns:ns20="xml" ns20:lang="en">Urinary C4d does not correlate with C4d-staining in peritubular capillaries but reflects nonspecific glomerular injury.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>