<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Quail DF</dc:creator>
  <dc:creator>Joyce JA</dc:creator>
  <dc:date>2017</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here, we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment. We also highlight recent advances in therapeutically targeting the brain TME in cancer. By developing a comprehensive understanding of the complex and interconnected microenvironmental landscape of brain malignancies we will greatly expand the range of therapeutic strategies available to target these deadly diseases.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/560</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ccell.2017.02.009</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/28292436</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Cancer cell. - 2017</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">blood-brain barrier</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">brain metastasis</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">brain tumor microenvironment</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">glioma</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">immunotherapy</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">tumor-associated macrophage</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Blood-Brain Barrier</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Brain Neoplasms</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Dendritic Cells</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Macrophages</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Microglia</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Neovascularization, Physiologic</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Neutrophils</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">T-Lymphocytes</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Tumor Microenvironment</dc:subject>
  <dc:subject xmlns:ns17="xml" ns17:lang="en">Wound Healing</dc:subject>
  <dc:title xmlns:ns18="xml" ns18:lang="en">The Microenvironmental Landscape of Brain Tumors.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>