Eicher T Brandstätter L Pos KM 2009 The tripartite efflux system AcrA/AcrB/TolC is the main pump in Escherichia coli for the efflux of multiple antibiotics, dyes, bile salts and detergents. The inner membrane component AcrB is central to substrate recognition and energy transduction and acts as a proton/drug antiporter. Recent structural studies show that homotrimeric AcrB can adopt different monomer conformations representing consecutive states in an allosteric functional rotation transport cycle. The conformational changes create an alternate access drug transport tunnel including a hydrophobic substrate binding pocket in one of the cycle intermediates. application/pdf https://sonar.ch/global/documents/57228 eng info:eu-repo/semantics/altIdentifier/doi/10.1515/BC.2009.090 info:eu-repo/semantics/altIdentifier/pmid/19453279 info:eu-repo/semantics/openAccess Biological chemistry. - 2009 Drug Resistance, Multiple, Bacterial Escherichia coli Proteins Models, Molecular Multidrug Resistance-Associated Proteins Substrate Specificity Structural and functional aspects of the multidrug efflux pump AcrB. http://purl.org/coar/resource_type/c_6501