<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Savoca R</dc:creator>
  <dc:creator>Ziegler U</dc:creator>
  <dc:creator>Sonderegger P</dc:creator>
  <dc:date>1995</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">We have examined the influence of amino acids on chicken embryonic dorsal root ganglion (DRG) neurons in vitro and have found that serine has a marked impact on the morphology of the developing neurites. In cultures supplemented with L-serine (but not D-serine) at micromolar concentrations (10-200 microM), the length of the neurites was increased by up to 100% and they were seen to develop a more complex branching pattern. These effects of L-serine were found to be concentration-dependent and stereospecific and were observed on several different substrata such as laminin, Ng-CAM and axonin-1. Similar observations were also made in the case of embryonic retinal explants, while the addition of non-essential amino acids other than L-serine to DRG neurons was found to have no effect. We conclude that, although belonging to the group of non-essential amino acids and not a recognized neurotransmitter, L-serine is an important factor for the morphological differentiation of neurons in vitro.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/60601</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/0165-0270(95)00038-v</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/8618415</dc:relation>
  <dc:source>Journal of neuroscience methods. - 1995</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Cell Count</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Chick Embryo</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Ganglia, Spinal</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">In Vitro Techniques</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Neurites</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Neurons</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Serine</dc:subject>
  <dc:title xmlns:ns9="xml" ns9:lang="en">Effects of L-serine on neurons in vitro.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>