Bruckner-Tuderman L Vogel A Rüegger S Odermatt B Tönz O Schnyder UW 1989 A patient with epidermolysis bullosa simplex with mottled pigmentation is described. Clinical features include blistering of the skin, especially of the extremities; healing without scars; slight atrophy of the skin; and striking mottled pigmentation of the trunk. Histologic examination of a biopsy specimen from freshly frictioned, clinically uninvolved skin indicated a split inside the basal keratinocytes, focal hyperpigmentation of the basal cells, and pigment incontinence without an inflammatory infiltrate. Indirect immunofluorescence demonstrated focal discontinuity of the basement membrane zone. Electron microscopic examination revealed basal keratinocytes with few intact intracellular organelles, aggregated tonofilaments, and subnuclear splitting with the basal parts of the cells adhering to the basement membrane. Both normal basement membrane and zones of irregular and interrupted structures were seen. Hemidesmosomes and anchoring fibrils appeared to be normal. https://sonar.ch/global/documents/60738 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/s0190-9622(89)80052-0 info:eu-repo/semantics/altIdentifier/pmid/2474016 Journal of the American Academy of Dermatology. - 1989 Adolescent Atrophy Basement Membrane Biopsy Epidermis Epidermolysis Bullosa Fluorescent Antibody Technique Humans Keratins Male Microscopy, Electron Pigmentation Disorders Epidermolysis bullosa simplex with mottled pigmentation. http://purl.org/coar/resource_type/c_6501