<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Czarnetzki C</dc:creator>
  <dc:creator>Lysakowski C</dc:creator>
  <dc:creator>Elia N</dc:creator>
  <dc:creator>Tramèr MR</dc:creator>
  <dc:date>2010</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">BACKGROUND
A previously published study suggested that pre-treatment with magnesium sulphate (MgSO(4)) had no impact on the speed of onset of rocuronium-induced neuromuscular block. We set out to verify this assumption.


METHODS
Eighty patients (18-60 years) were randomly allocated to MgSO(4) 60 mg/kg or placebo (saline). Study drugs were given intravenously for 15 min before induction of anaesthesia with propofol, sufentanil and rocuronium 0.6 mg/kg. Anaesthesia was maintained with a target-controlled propofol infusion. Neuromuscular transmission was measured using train-of-four (TOF)-Watch SX acceleromyography.


RESULTS
Onset was analysed in 37 MgSO(4) and 38 saline patients, and recovery in 35 MgSO(4) and 37 saline patients. Onset time (to 95% depression of T1) was on average 77 [SD=18] s with MgSO(4) and 120 [48] s with saline (P&lt;0.001). The total recovery time (DurTOF0.9) was on average 73.2 [22] min with MgSO(4) and 57.8 [14.2] min with saline (P&lt;0.003). The clinical duration (Dur25%) was on average 44.7 [14] min with MgSO(4) and 33.2 [8.1] min with saline (P&lt;0.0002). The recovery index (Dur25-75%) was on average 14.0 [6] min with MgSO(4) and 11.2 [5.2] min with saline (P&lt;0.02). The recovery time (Dur25%TOF0.9) was on average 28.5 [11.7] min with MgSO(4) and 24.7 [8.4] min with saline (P=0.28).


CONCLUSION
Magnesium sulphate given 15 min before propofol anaesthesia reduces the onset time of rocuronium by about 35% and prolongs the total recovery time by about 25%.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/62043</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1399-6576.2009.02160.x</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/19919585</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Acta anaesthesiologica Scandinavica. - 2010</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Adjuvants, Anesthesia</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Adolescent</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Adult</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Androstanols</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Anesthesia Recovery Period</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Anesthesia, General</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Data Interpretation, Statistical</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Electric Stimulation</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Endpoint Determination</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Female</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Injections, Intravenous</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Magnesium Sulfate</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Male</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Middle Aged</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Myography</dc:subject>
  <dc:subject xmlns:ns17="xml" ns17:lang="en">Neuromuscular Blockade</dc:subject>
  <dc:subject xmlns:ns18="xml" ns18:lang="en">Neuromuscular Nondepolarizing Agents</dc:subject>
  <dc:subject xmlns:ns19="xml" ns19:lang="en">Premedication</dc:subject>
  <dc:subject xmlns:ns20="xml" ns20:lang="en">Rocuronium</dc:subject>
  <dc:subject xmlns:ns21="xml" ns21:lang="en">Time Factors</dc:subject>
  <dc:subject xmlns:ns22="xml" ns22:lang="en">Young Adult</dc:subject>
  <dc:title xmlns:ns23="xml" ns23:lang="en">Time course of rocuronium-induced neuromuscular block after pre-treatment with magnesium sulphate: a randomised study.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>