<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Bampi C</dc:creator>
  <dc:creator>Grenet AS</dc:creator>
  <dc:creator>Caignard G</dc:creator>
  <dc:creator>Vidalain PO</dc:creator>
  <dc:creator>Roux L</dc:creator>
  <dc:date>2013</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">The cellular tail-interacting 47-kDa protein (TIP47) acts positively on HIV-1 and vaccinia virus production. We show here that TIP47, in contrast, acts as a restriction factor for Sendai virus production. This conclusion is supported by the occurrence of increased or decreased virus production upon its suppression or overexpression, respectively. Pulse-chase metabolic labeling of viral proteins under conditions of TIP47 suppression reveals an increased rate of viral protein synthesis followed by increased incorporation of viral proteins into virus particles. TIP47 is here described for the first time as a viral restriction factor that acts by limiting viral protein synthesis.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/62153</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.virusres.2013.01.006</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/23348195</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Virus research. - 2013</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Cell Line</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Cricetinae</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Gene Expression</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Gene Knockdown Techniques</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">HIV-1</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Perilipin-3</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Proteins</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Sendai virus</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Vesicular Transport Proteins</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Viral Load</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Virion</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Virus Replication</dc:subject>
  <dc:title xmlns:ns15="xml" ns15:lang="en">The cellular protein TIP47 restricts Respirovirus multiplication leading to decreased virus particle production.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>