Stadler BM Rudolf MP Zürcher AW Miescher S Vogel M 1996 Anti-IgE autoantibodies exist predominantly in the sera of patients with atopic disease. For some time such anti-IgE autoantibodies have been considered a phenomenon that may not be of clinical importance. The cloning of such anti-IgE autoantibodies has eliminated doubts of whether these antibodies exist, but it is still unclear whether such autoantibodies play a pathophysiological role. However, there are ongoing clinical trials that use humanized anti-IgE antibodies for passive immunization of atopic individuals. While this approach may not definitely clarify the role of anti-IgE autoantibodies, it will nevertheless clarify the role of IgE. https://sonar.ch/global/documents/63669 eng info:eu-repo/semantics/altIdentifier/doi/10.1038/icb.1996.27 info:eu-repo/semantics/altIdentifier/pmid/8724009 Immunology and cell biology. - 1996 Animals Antibodies, Monoclonal Autoantibodies Cloning, Molecular Humans Hypersensitivity, Immediate Immunization Immunoglobulin E Vaccines Anti-IgE in allergic sensitization. http://purl.org/coar/resource_type/c_6501