<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Stadler MB</dc:creator>
  <dc:creator>Arnold D</dc:creator>
  <dc:creator>Frieden S</dc:creator>
  <dc:creator>Luginbühl S</dc:creator>
  <dc:creator>Stadler BM</dc:creator>
  <dc:date>2005</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">It is still elusive why certain self proteins induce an autoimmune response. One immunological hypothesis is that only modified or altered self-proteins may become a target. Thus, we asked whether such alterations may actually be genetic polymorphisms that can be revealed by analyzing sequence variability in the known human autoantigens. Indeed, we found autoantigens to contain significantly more single nucleotide polymorphisms (SNP) than other human genes do. Our finding may offer an explanation for autoimmune responses through allogeneic exposure. Besides other contributing factors in autoimmunity, SNP may represent an essential prerequisite for the primary induction of an autoimmune response.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/6496</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1002/eji.200425481</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/15627977</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>European journal of immunology. - 2005</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Amino Acid Sequence</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Autoantigens</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Autoimmune Diseases</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Autoimmunity</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Chromosome Mapping</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Databases, Genetic</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Epitopes</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Molecular Sequence Data</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Multigene Family</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Polymorphism, Single Nucleotide</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Self Tolerance</dc:subject>
  <dc:title xmlns:ns13="xml" ns13:lang="en">Single nucleotide polymorphisms as a prerequisite for autoantigens.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>