<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Stieger B</dc:creator>
  <dc:creator>Hagenbuch B</dc:creator>
  <dc:date>2014</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Organic anion-transporting polypeptides or OATPs are central transporters in the disposition of drugs and other xenobiotics. In addition, they mediate transport of a wide variety of endogenous substrates. The critical role of OATPs in drug disposition has spurred research both in academia and in the pharmaceutical industry. Translational aspects with clinical questions are the focus in academia, while the pharmaceutical industry tries to define and understand the role these transporters play in pharmacotherapy. The present overview summarizes our knowledge on the interaction of food constituents with OATPs and on the OATP transport mechanisms. Further, it gives an update on the available information on the structure-function relationship of the OATPs and, finally, covers the transcriptional and posttranscriptional regulation of OATPs.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/66181</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/B978-0-12-800223-0.00005-0</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/24745984</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Current topics in membranes. - 2014</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Drug</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">OATP</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Organic anion</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Transport</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Biological Products</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Biological Transport</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Gene Expression Regulation</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Organic Anion Transporters</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Protein Processing, Post-Translational</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Transcription, Genetic</dc:subject>
  <dc:title xmlns:ns13="xml" ns13:lang="en">Organic anion-transporting polypeptides.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>