Pink A Anzengruber F Navarini AA 2018 Acne and hidradenitis suppurativa (HS) both centre on hair follicles. They often occur together as part of the acne tetrad, but are found in distinct localizations. Acne is primarily defined by the presence of comedones and inflammatory lesions. However, in HS the intertriginous localization and chronicity play equally important roles for the diagnosis to the inflammatory lesions. Genetics, bacteria, environmental factors and innate inflammation have all been found to play a role in acne and/or HS. Surprisingly, there is little overlap between the findings so far. The genetics of acne and HS are distinct, bacteria have not been shown convincingly to play a role in HS, and the important risk factors obesity and smoking in HS cannot be easily translated to acne. The one driving factor central to both diseases is innate inflammation, most strikingly involving interleukin-1. Hence the interleukin-1 family, as already shown in autoinflammatory conditions associated with acne, could represent attractive treatment targets. https://sonar.ch/global/documents/67322 eng info:eu-repo/semantics/altIdentifier/doi/10.1111/bjd.16231 info:eu-repo/semantics/altIdentifier/pmid/29380349 The British journal of dermatology. - 2018 Acne Vulgaris Adolescent Adult Bacterial Infections Child Cytokines Female Hair Diseases Hair Follicle Hidradenitis Suppurativa Hormones Humans Immunity, Cellular Male Mutation, Missense Obesity Phenotype Sebaceous Gland Diseases Smoking Young Adult Acne and hidradenitis suppurativa. http://purl.org/coar/resource_type/c_6501