Seiser T Saget T Tran DN Cramer N 2011 The exploitation of ring strain as a driving force to facilitate chemical reactions is a well-appreciated principle in organic chemistry. The most prominent and most frequently used compound classes in this respect are oxiranes and cyclopropanes. For rather a long time, cyclobutanes lagged behind these three-membered-ring compounds in their development as reactive substrates, but during the past decade an increasing number of useful reactions of four-membered-ring substrates have emerged. This Minireview examines corresponding catalytic reactions ranging from Lewis or Brønsted acid catalyzed processes to enzymatic reactions. The main focus is placed on transition-metal-catalyzed C-C bond-insertion and β-carbon-elimination processes, which enable exciting downstream reactions that deliver versatile building blocks. https://sonar.ch/global/documents/67982 eng info:eu-repo/semantics/altIdentifier/doi/10.1002/anie.201101053 info:eu-repo/semantics/altIdentifier/pmid/21793133 Angewandte Chemie (International ed. in English). - 2011 Cyclobutanes in catalysis. http://purl.org/coar/resource_type/c_6501