Zangari J Petrelli F Maillot B Martinou JC 2020 Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondrial pyruvate carrier (MPC). In this review, we report the latest findings on the physiology of the MPC and we discuss how a dysfunctional MPC can lead to diverse pathologies, including neurodegenerative diseases, metabolic disorders, and cancer. application/pdf https://sonar.ch/global/documents/70427 eng info:eu-repo/semantics/altIdentifier/doi/10.3390/biom10071068 info:eu-repo/semantics/altIdentifier/pmid/32708919 info:eu-repo/semantics/openAccess Biomolecules. - 2020 cancer metabolic disorders metabolism mitochondria mitochondrial pyruvate carrier neurodegeneration The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier. http://purl.org/coar/resource_type/c_6501