<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Diviani D</dc:creator>
  <dc:creator>Dodge-Kafka KL</dc:creator>
  <dc:creator>Li J</dc:creator>
  <dc:creator>Kapiloff MS</dc:creator>
  <dc:date>2011</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">The pleiotropic cyclic nucleotide cAMP is the primary second messenger responsible for autonomic regulation of cardiac inotropy, chronotropy, and lusitropy. Under conditions of prolonged catecholaminergic stimulation, cAMP also contributes to the induction of both cardiac myocyte hypertrophy and apoptosis. The formation of localized, multiprotein complexes that contain different combinations of cAMP effectors and regulatory enzymes provides the architectural infrastructure for the specialization of the cAMP signaling network. Scaffolds that bind protein kinase A are called "A-kinase anchoring proteins" (AKAPs). In this review, we discuss recent advances in our understanding of how PKA is compartmentalized within the cardiac myocyte by AKAPs and how AKAP complexes modulate cardiac function in both health and disease.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/78151</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpheart.00569.2011</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/21856912</dc:relation>
  <dc:source>American journal of physiology. Heart and circulatory physiology. - 2011</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">A Kinase Anchor Proteins</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Cardiovascular Agents</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Cyclic AMP</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Cyclic AMP-Dependent Protein Kinases</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Heart Diseases</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Myocardium</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Second Messenger Systems</dc:subject>
  <dc:title xmlns:ns10="xml" ns10:lang="en">A-kinase anchoring proteins: scaffolding proteins in the heart.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>