<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Müller JA</dc:creator>
  <dc:creator>Bockisch CJ</dc:creator>
  <dc:creator>Tarnutzer AA</dc:creator>
  <dc:date>2016</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">OBJECTIVE
Acute unilateral peripheral-vestibular hypofunction (UVH) shifts the subjective visual vertical (SVV) ipsilesionally, triggering central compensation that usually eliminates shifts when upright. We hypothesized that compensation is worse when roll-tilted.


METHODS
We quantified SVV errors and variability in different roll-tilted positions (0°, ±45°, ±90°) in patients with chronic UVH affecting the superior branch (SVN; n=4) or the entire (CVN; n=9) vestibular nerve.


RESULTS
Errors in SVN and CVN were not different. When roll-tilted ipsilesionally 45° (9.6±5.4° vs. -0.2±6.4°, patients vs. controls, p&lt;0.001) and 90° (23.5±5.7° vs. 16.8±8.8°, p=0.003), the patient's SVV was shifted significantly towards the lesioned ear. When upright, only a trend was noted (3.6±2.2° vs. 0.0±1.2°, p=0.099); for contralesional roll-tilts shifts were not different from controls. Variability was larger for CVN than SVN (p=0.046). With increasing disease-duration, adjustment errors decayed for ipsilesional roll-tilt and upright (p⩽0.025).


CONCLUSIONS
The reason verticality perception was distorted for ipsilesional roll-tilts, may be the insufficient integration of contralesional otolith-input. Similar errors in SVN and CVN suggest a dominant utricular role in verticality perception, albeit the sacculus may improve precision of SVV estimates.


SIGNIFICANCE
With deficiencies in central compensation being roll-angle dependent, extending SVV-testing to roll-tilted positions may improve identifying patients with chronic UVH.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/81657</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.clinph.2016.07.010</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/27522490</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. - 2016</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Graviception</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Otolith organs</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Sacculus</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Subjective visual vertical</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Utriculus</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Vestibular neuropathy</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Adult</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Aged</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Female</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Male</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Middle Aged</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Otolithic Membrane</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Space Perception</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Spatial Navigation</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Vestibular Diseases</dc:subject>
  <dc:title xmlns:ns17="xml" ns17:lang="en">Spatial orientation in patients with chronic unilateral vestibular hypofunction is ipsilesionally distorted.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>