Tiefenauer LX Kossek S Padeste C Thiébaud P 1997 In contrast to optical immunosensors, the electrochemical detection of an immunanalytical reaction does require a labeling, but allows an easier discrimination of specific and non-specific binding. We present a concept and first results for a multivalent amperometric immunosensor system which is based on silicon technology. The capture molecule streptavidin, covalently immobilized on silica, allows the immobilization of biotinylated antigens at a defined density. A nanostructured gold electrode serving as a stable network of nanowires is expected to be beneficial for the electrochemical detection of bound ferrocene-labeled antibody molecules. The results presented focus on site-specific immobilization of streptavidin on silica and reduction of non-specific binding of proteins. https://sonar.ch/global/documents/83181 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/s0956-5663(97)85339-0 info:eu-repo/semantics/altIdentifier/pmid/9115689 Biosensors & bioelectronics. - 1997 Bacterial Proteins Biosensing Techniques Electrochemistry Electrodes Enzyme-Linked Immunosorbent Assay Evaluation Studies as Topic Gold Silicon Dioxide Streptavidin Towards amperometric immunosensor devices. http://purl.org/coar/resource_type/c_6501