Hata Y Ebrahimi SN De Mieri M Zimmermann S Mokoka T Naidoo D Fouche G Maharaj V Kaiser M Brun R Potterat O Hamburger M 2014 Human African trypanosomiasis is a neglected tropical disease in sub Saharan Africa that is fatal if left untreated. In a search for new natural products with antitrypanosomal activity, we recently identified abruquinones B and I from Abrus precatorius as potent in vitro trypanocidal compounds with high selectivity indices. To obtain sufficient compound for in vivo efficacy tests in mice, a second batch of plant material was re-collected and extracted. However, the chemical profiles of the two batches differed, and additional abruquinones were isolated and identified by HR-ESI-MS, and 1D and 2D NMR ((1)H, (13)C, COSY, HMBC, HSQC, and NOESY) spectroscopy. Abruquinones J (1), K (2), and L (3) were new, while abruquinones A (4) and D (5) were known from the first batch of plant material. The absolute configuration of compounds 1 to 3 was determined by comparison of electronic circular dichroism (ECD) spectra with calculated ECD data. Compounds 2 to 5 showed high in vitro activity against T. b. rhodesiense (IC50 of 0.01, 0.02, 0.02 and 0.01 μM, respectively), and remarkable SIs of 508, 374, 1379, and 668, respectively. https://sonar.ch/global/documents/8608 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fitote.2013.12.015 info:eu-repo/semantics/altIdentifier/pmid/24382449 Fitoterapia. - 2014 Abrus precatorius ECD Fabaceae Isoflavan quinone Trypanosoma brucei rhodesiense Abrus Animals Benzopyrans Benzoquinones Microbial Sensitivity Tests Rats Trypanocidal Agents Antitrypanosomal isoflavan quinones from Abrus precatorius. http://purl.org/coar/resource_type/c_6501