Zhu X Yan J Bregere C Zelmer A Goerne T Kapfhammer JP Guzman R Wellmann S 2019 Hypoxic ischemia (HI) is an acute brain threat across all age groups. Therapeutic hypothermia ameliorates resulting injury in neonates but its side effects prevent routine use in adults. Hypothermia up-regulates a small protein subset that includes RNA-binding motif protein 3 (RBM3), which is neuroprotective under stressful conditions. Here we show how RBM3 stimulates neuronal differentiation and inhibits HI-induced apoptosis in the two areas of persistent adult neurogenesis, the subventricular zone (SVZ) and the subgranular zone (SGZ), while promoting neural stem/progenitor cell (NSPC) proliferation after HI injury only in the SGZ. RBM3 interacts with IGF2 mRNA binding protein 2 (IMP2), elevates its expression and thereby stimulates IGF2 release in SGZ but not SVZ-NSPCs. In summary, we describe niche-dependent regulation of neurogenesis after adult HI injury via the novel RBM3-IMP2-IGF2 signaling pathway. application/pdf https://sonar.ch/global/documents/92702 eng info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-019-11870-x info:eu-repo/semantics/altIdentifier/pmid/31484925 info:eu-repo/semantics/openAccess Nature communications. - 2019 Animals Animals, Newborn Brain Injuries Cells, Cultured HEK293 Cells Hippocampus Humans Hypoxia-Ischemia, Brain Insulin-Like Growth Factor II Lateral Ventricles Male Mice, Inbred C57BL Mice, Knockout Neural Stem Cells Neurogenesis RNA-Binding Proteins Signal Transduction Stem Cell Niche RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury. http://purl.org/coar/resource_type/c_6501