Styczyński J Tridello G Koster L Iacobelli S van Biezen A van der Werf S Mikulska M Gil L Cordonnier C Ljungman P Averbuch D Cesaro S de la Camara R Baldomero H Bader P Basak G Bonini C Duarte R Dufour C Kuball J Lankester A Montoto S Nagler A Snowden JA Kröger N Mohty M Gratwohl A 2020 Information on incidence, and factors associated with mortality is a prerequisite to improve outcome after hematopoietic stem cell transplantation (HSCT). Therefore, 55'668 deaths in 114'491 patients with HSCT (83.7% allogeneic) for leukemia were investigated in a landmark analysis for causes of death at day 30 (very early), day 100 (early), at 1 year (intermediate) and at 5 years (late). Mortality from all causes decreased from cohort 1 (1980-2001) to cohort 2 (2002-2015) in all post-transplant phases after autologous HSCT. After allogeneic HSCT, mortality from infections, GVHD, and toxicity decreased up to 1 year, increased at 5 years; deaths from relapse increased in all post-transplant phases. Infections of unknown origin were the main cause of infectious deaths. Lethal bacterial and fungal infections decreased from cohort 1 to cohort 2, not unknown or mixed infections. Infectious deaths were associated with patient-, disease-, donor type, stem cell source, center, and country- related factors. Their impact varied over the post-transplant phases. Transplant centres have successfully managed to reduce death after HSCT in the early and intermediate post-transplant phases, and have identified risk factors. Late post-transplant care could be improved by focus on groups at risk and better identification of infections of "unknown origin". application/pdf https://sonar.ch/global/documents/92776 eng info:eu-repo/semantics/altIdentifier/doi/10.1038/s41409-019-0624-z info:eu-repo/semantics/altIdentifier/pmid/31455899 info:eu-repo/semantics/openAccess Bone marrow transplantation. - 2020 Transplantation Hematology Death after hematopoietic stem cell transplantation: changes over calendar year time, infections and associated factors. http://purl.org/coar/resource_type/c_6501