<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>López-Centeno B</dc:creator>
  <dc:creator>Badenes-Olmedo C</dc:creator>
  <dc:creator>Mataix-Sanjuan A</dc:creator>
  <dc:creator>Bellón JM</dc:creator>
  <dc:creator>Pérez-Latorre L</dc:creator>
  <dc:creator>López JC</dc:creator>
  <dc:creator>Benedí J</dc:creator>
  <dc:creator>Khoo S</dc:creator>
  <dc:creator>Marzolini C</dc:creator>
  <dc:creator>Calvo-Alcántara MJ</dc:creator>
  <dc:creator>Berenguer J</dc:creator>
  <dc:date>2020</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">OBJECTIVES
We assessed the prevalence of potentially inappropriate medication (PIM) among older (≥ 65 years) people living with HIV (O-PLWH) in the region of Madrid.


METHODS
We analysed the dispensation registry of community and hospital pharmacies from the Madrid Regional Health Service (SERMAS) for the period between 1 January and 30 June 2017, looking specifically at PIMs according to the 2019 Beers criteria. Co-medications were classified according to the Anatomical Therapeutic Chemical (ATC) classification system.


RESULTS
A total of 6 636 451 individuals received medications. Of these individuals, 22 945 received antiretrovirals (ARVs), and of these 1292 were O-PLWH. Overall, 1135 (87.8%) O-PLWH were taking at least one co-medication, and polypharmacy (at least five co-medications) was observed in 852 individuals (65.9%). A PIM was identified in 482 (37.3%) O-PLWH. Factors independently associated with PIM were polypharmacy [adjusted odds ratio (aOR) 7.08; 95% confidence interval (CI) 5.16-9.72] and female sex (aOR 1.75; 95% CI 1.30-2.35). The distribution of PIMs according to ATC drug class were nervous system drugs (n = 369; 28.6%), musculoskeletal system drugs (n = 140; 10.8%), gastrointestinal and metabolism drugs (n = 72; 5.6%), cardiovascular drugs (n = 61; 4.7%), respiratory system drugs (n = 13; 1.0%), antineoplastic and immunomodulating drugs (n = 10; 0.8%), and systemic anti-infectives (n = 2; 0.2%). Five drugs accounted for 84.8% of the 482O PLWH with PIMs: lorazepam (38.2%), ibuprofen (18.0%), diazepam (10.2%), metoclopramide (9.9%), and zolpidem (8.5%).


CONCLUSIONS
Prescription of PIMs is highly prevalent in O-PLWH. Consistent with data in uninfected elderly people, the most frequently observed PIMs were benzodiazepines and nonsteroidal anti-inflammatory drugs . Targeted interventions are warranted to reduce inappropriate prescribing and polypharmacy in this vulnerable population.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/94164</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/hiv.12883</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/32516849</dc:relation>
  <dc:source>HIV medicine. - 2020</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">HIV</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">aging</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">antiretroviral drugs</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">polypharmacy</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">potentially inappropriate medication</dc:subject>
  <dc:title xmlns:ns6="xml" ns6:lang="en">Potentially inappropriate medications in older adults living with HIV.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>