Exner CJ Turks M Fonquerne F Vogel P 2011 Herein, a major breakthrough in a sulfur dioxide-mediated oxyallylation cascade reaction is reported that allows the preparation of complex long-chain polyketide fragments with more than ten stereogenic centers through a carefully designed desymmetrization process. An allylbissilane is combined, under the appropriate reaction conditions, with two different 1,3-dioxy-1,3-dienes permitting the construction of a 13-membered polypropionate precursor in one pot. Four stereocenters are selectively created during this process. The so-obtained pseudo-C(2)- or -C(S)-symmetric products are desymmetrized through selective deprotection and can be selectively elongated in both directions using aldol chemistry. https://sonar.ch/global/documents/96925 eng info:eu-repo/semantics/altIdentifier/doi/10.1002/chem.201003264 info:eu-repo/semantics/altIdentifier/pmid/21387431 Chemistry (Weinheim an der Bergstrasse, Germany). - 2011 Alkenes Molecular Structure Propionates Silanes Stereoisomerism Sulfur Dioxide Concise synthesis of complicated polypropionates through one-pot dissymmetrical two-directional chain elongation. http://purl.org/coar/resource_type/c_6501