Trono D 2012 The use of integrating vectors for gene therapy - required for stable correction of gene expression - carries the risk of insertional mutagenesis, which can lead to activation of a tumorigenic program. In this issue of the JCI, Moiani et al. and Cesana et al. investigate how viral vectors can induce aberrant splicing, resulting in chimeric cellular-viral transcripts. The finding that this is a general phenomenon is concerning, but some of their results do suggest approaches for the development of safeguards in gene therapy vector design. application/pdf https://sonar.ch/global/documents/96932 eng info:eu-repo/semantics/altIdentifier/doi/10.1172/JCI63066 info:eu-repo/semantics/altIdentifier/pmid/22523063 info:eu-repo/semantics/openAccess The Journal of clinical investigation. - 2012 Alternative Splicing Genome, Human Humans Lentivirus Lentivirus Infections Protein Isoforms Transcriptome Virus Integration Gene therapy: too much splice can spoil the dish. http://purl.org/coar/resource_type/c_6501