<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Grabmaier U</dc:creator>
  <dc:creator>Kania G</dc:creator>
  <dc:creator>Kreiner J</dc:creator>
  <dc:creator>Grabmeier J</dc:creator>
  <dc:creator>Uhl A</dc:creator>
  <dc:creator>Huber BC</dc:creator>
  <dc:creator>Lackermair K</dc:creator>
  <dc:creator>Herbach N</dc:creator>
  <dc:creator>Todica A</dc:creator>
  <dc:creator>Eriksson U</dc:creator>
  <dc:creator>Weckbach LT</dc:creator>
  <dc:creator>Brunner S</dc:creator>
  <dc:date>2016</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Vascular cell adhesion molecule-1 (VCAM-1) is strongly upregulated in hearts of mice with coxsackie virus-induced as well as in patients with viral infection-triggered dilated cardiomyopathy. Nevertheless, the role of its soluble form as a biomarker in inflammatory heart diseases remains unclear. Therefore, we investigated whether plasma levels of soluble VCAM-1 (sVCAM-1) directly correlated with disease activity and progression of cardiac dysfunction in the mouse model of experimental autoimmune myocarditis (EAM). EAM was induced by immunization of BALB/c mice with heart-specific myosin-alpha heavy chain peptide together with complete Freund`s adjuvant. ELISA revealed strong expression of cardiac VCAM-1 (cVCAM-1) throughout the course of EAM in immunized mice compared to control animals. Furthermore, sVCAM-1 was elevated in the plasma of immunized compared to control mice at acute and chronic stages of the disease. sVCAM-1 did not correlate with the degree of acute cardiac inflammation analyzed by histology or cardiac cytokine expression investigated by ELISA. Nevertheless, heart to body weight ratio correlated significantly with sVCAM-1 at chronic stages of EAM. Cardiac systolic dysfunction studied with positron emission tomography indicated a weak relationship with sVCAM-1 at the chronic stage of the disease. Our data provide evidence that plasma levels of sVCAM-1 are elevated throughout all stages of the disease but showed no strong correlation with the severity of EAM.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/96978</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0158299</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/27501319</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>PloS one. - 2016</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Autoimmune Diseases</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Biomarkers</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Cytokines</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Disease Models, Animal</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Immunization</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Inflammation</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Male</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Mice</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Mice, Inbred BALB C</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Myocarditis</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Vascular Cell Adhesion Molecule-1</dc:subject>
  <dc:title xmlns:ns13="xml" ns13:lang="en">Soluble Vascular Cell Adhesion Molecule-1 (VCAM-1) as a Biomarker in the Mouse Model of Experimental Autoimmune Myocarditis (EAM).</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>