Fujioka H Uno SN Kamiya M Kojima R Johnsson K Urano Y 2020 We show that the equilibrium of intramolecular spirocyclization of coumarin-hemicyanine hybrid fluorophores can be finely tuned by means of chemical modifications. We used this scaffold to develop activatable fluorescent probes with large Stokes shifts for γ-glutamyltranspeptidase and esterase. https://sonar.ch/global/documents/96989 eng info:eu-repo/semantics/altIdentifier/doi/10.1039/d0cc00559b info:eu-repo/semantics/altIdentifier/pmid/32297612 Chemical communications (Cambridge, England). - 2020 Materials Chemistry Electronic, Optical and Magnetic Materials General Chemistry Surfaces, Coatings and Films Metals and Alloys Ceramics and Composites Catalysis Activatable fluorescent probes for hydrolase enzymes based on coumarin-hemicyanine hybrid fluorophores with large Stokes shifts. http://purl.org/coar/resource_type/c_6501