Mota LJ Sorg I Cornelis GR 2005 Type III secretion (T3S) is an export pathway used by Gram-negative pathogenic bacteria to inject bacterial proteins into the cytosol of eukaryotic host cells. This pathway is characterized by (i) a secretion nanomachine related to the bacterial flagellum, but usually topped by a stiff needle-like structure; (ii) the assembly in the eukaryotic cell membrane of a translocation pore formed by T3S substrates; (iii) a non-cleavable N-terminal secretion signal; (iv) T3S chaperones, assisting the secretion of some substrates; (v) a control mechanism ensuring protein delivery at the right place and time. Here, we review these different aspects focusing in open questions that promise exciting findings in the near future. application/pdf https://sonar.ch/global/documents/97622 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.femsle.2005.08.036 info:eu-repo/semantics/altIdentifier/pmid/16216444 info:eu-repo/semantics/openAccess FEMS microbiology letters. - 2005 Animals Bacterial Proteins Eukaryotic Cells Gene Expression Regulation, Bacterial Gram-Negative Bacteria Gram-Negative Bacterial Infections Humans Protein Transport Virulence Type III secretion: the bacteria-eukaryotic cell express. http://purl.org/coar/resource_type/c_6501