The role of FXR in disorders of bile acid homeostasis.
- Eloranta JJ Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland. jyrki.eloranta@usz.ch
- Kullak-Ublick GA
- 2008-10-18
Published in:
- Physiology (Bethesda, Md.). - 2008
Animals
Bile Acids and Salts
Biliary Tract Diseases
DNA-Binding Proteins
Homeostasis
Humans
Intestines
Ligands
Liver Diseases
Receptors, Cytoplasmic and Nuclear
Transcription Factors
English
As ligands for the nuclear receptor FXR, bile acids regulate their own synthesis, transport, and conjugation, thus protecting against bile acid toxicity. Recently, the role of genetic variants in FXR itself, FXR target genes, and regulators of FXR in the pathophysiology of the liver and intestine has become increasingly evident.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1152/physiol.00020.2008
- PMID 18927204
- Persistent URL
- https://sonar.ch/global/documents/119585
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