Journal article
Increased rates of intermittent rhythmic delta and theta activity in the electroencephalographies of adult patients with attention-deficit hyperactivity disorder.
- Endres D Section for Experimental Neuropsychiatry, Department of Psychiatry, Faculty of Medicine, University of Freiburg, Hauptstr. 5, 79104 Freiburg, Germany. Electronic address: dominique.endres@uniklinik-freiburg.de.
- Maier S Section for Experimental Neuropsychiatry, Department of Psychiatry, Faculty of Medicine, University of Freiburg, Hauptstr. 5, 79104 Freiburg, Germany. Electronic address: simon.maier@uniklinik-freiburg.de.
- Feige B Section for Experimental Neuropsychiatry, Department of Psychiatry, Faculty of Medicine, University of Freiburg, Hauptstr. 5, 79104 Freiburg, Germany. Electronic address: bernd.feige@uniklinik-freiburg.de.
- Mokhtar NB Section for Experimental Neuropsychiatry, Department of Psychiatry, Faculty of Medicine, University of Freiburg, Hauptstr. 5, 79104 Freiburg, Germany.
- Nickel K Section for Experimental Neuropsychiatry, Department of Psychiatry, Faculty of Medicine, University of Freiburg, Hauptstr. 5, 79104 Freiburg, Germany. Electronic address: kathrin.nickel@uniklinik-freiburg.de.
- Goll P Section for Experimental Neuropsychiatry, Department of Psychiatry, Faculty of Medicine, University of Freiburg, Hauptstr. 5, 79104 Freiburg, Germany. Electronic address: peter.goll@uniklinik-freiburg.de.
- Meyer SA Section for Experimental Neuropsychiatry, Department of Psychiatry, Faculty of Medicine, University of Freiburg, Hauptstr. 5, 79104 Freiburg, Germany. Electronic address: simon.meyer@uniklinik-freiburg.de.
- Matthies S Section for Experimental Neuropsychiatry, Department of Psychiatry, Faculty of Medicine, University of Freiburg, Hauptstr. 5, 79104 Freiburg, Germany. Electronic address: swantje.matthies@uniklinik-freiburg.de.
- Ebert D Section for Experimental Neuropsychiatry, Department of Psychiatry, Faculty of Medicine, University of Freiburg, Hauptstr. 5, 79104 Freiburg, Germany. Electronic address: dieter.ebert@uniklinik-freiburg.de.
- Philipsen A Medical Campus University of Oldenburg, School of Medicine and Health Sciences, Psychiatry and Psychotherapy - University Hospital, Karl-Jaspers-Klinik, Hermann-Ehlers-Str. 7, 26160 Bad Zwischenahn, Germany. Electronic address: Alexandra.Philipsen@karl-jaspers-klinik.de.
- Perlov E Section for Experimental Neuropsychiatry, Department of Psychiatry, Faculty of Medicine, University of Freiburg, Hauptstr. 5, 79104 Freiburg, Germany; Clinic for Psychiatry Luzern, Schafmattstrasse 1, 4915 St. Urban, Switzerland. Electronic address: evgeniy.perlov@uniklinik-freiburg.de.
- Tebartz van Elst L Section for Experimental Neuropsychiatry, Department of Psychiatry, Faculty of Medicine, University of Freiburg, Hauptstr. 5, 79104 Freiburg, Germany. Electronic address: tebartzvanelst@uniklinik-freiburg.de.
- 2017-08-23
Published in:
- Epilepsy & behavior : E&B. - 2017
ADHD
Adults
EEG
IRDA
IRTA
LANI
Adult
Attention Deficit Disorder with Hyperactivity
Case-Control Studies
Child
Delta Rhythm
Electroencephalography
Female
Humans
Hyperventilation
Impulsive Behavior
Linear Models
Male
Theta Rhythm
English
INTRODUCTION
Adult attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. In subgroups of patients with a (para)epileptic pathomechanism, this might be due to intermittent rhythmic delta or theta activity (IRDA/IRTA).
PARTICIPANTS AND METHODS
Using a fully data-driven analysis, we compared the IRDA/IRTA rates in the resting electroencephalography (EEG) results of 97 adult patients with ADHD and 30 control subjects. The IRDA/IRTA rates before hyperventilation (HV) and for HV difference (difference between IRDA/IRTA rate after and before HV) were compared between groups using a linear model.
RESULTS
We detected significantly increased rates of IRDA/IRTA before HV (F=4.209, p=0.042) in patients with ADHD but no significant difference between the groups for HV-difference (F=2.46, p=0.119).
DISCUSSION
The increased IRDA/IRTA rates before HV in the group with ADHD might lead to (para)epileptic short-term effects (e.g., impulsivity) via local area network inhibition, and to long-term effects (e.g., cognitive deficits) via connectivistic brain restructuring.
Adult attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. In subgroups of patients with a (para)epileptic pathomechanism, this might be due to intermittent rhythmic delta or theta activity (IRDA/IRTA).
PARTICIPANTS AND METHODS
Using a fully data-driven analysis, we compared the IRDA/IRTA rates in the resting electroencephalography (EEG) results of 97 adult patients with ADHD and 30 control subjects. The IRDA/IRTA rates before hyperventilation (HV) and for HV difference (difference between IRDA/IRTA rate after and before HV) were compared between groups using a linear model.
RESULTS
We detected significantly increased rates of IRDA/IRTA before HV (F=4.209, p=0.042) in patients with ADHD but no significant difference between the groups for HV-difference (F=2.46, p=0.119).
DISCUSSION
The increased IRDA/IRTA rates before HV in the group with ADHD might lead to (para)epileptic short-term effects (e.g., impulsivity) via local area network inhibition, and to long-term effects (e.g., cognitive deficits) via connectivistic brain restructuring.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.yebeh.2017.06.039
- PMID 28830028
- Persistent URL
- https://sonar.ch/global/documents/138957
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