Journal article
Reduction in the death and cytolamination of developing neurons by tetrodotoxin in the axonal target region.
- Péquignot Y Institute of Anatomy, University of Lausanne, Switzerland.
- Clarke PG
- 1991-05-20
Published in:
- Brain research. Developmental brain research. - 1991
Animals
Axons
Brain
Carbocyanines
Cell Death
Chick Embryo
Electric Stimulation
Electrophysiology
Neurons
Retina
Tetrodotoxin
English
Tetrodotoxin was injected into one eye of chick embryos so as to block activity in the target territory of the isthmo-optic nucleus (ION) during its period of neuronal death. This markedly reduced the neuronal death and thereby prolonged the survival of some 'aberrantly' projecting neurons which would normally all die. In addition, the cytoarchitecture of the ION developed abnormally. Since these two effects differ markedly in their dose-dependence and in other ways, they cannot both be explained by changes in the strength of a single retrograde signal.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/0165-3806(91)90159-g
- PMID 1914148
- Persistent URL
- https://sonar.ch/global/documents/138999
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