Journal article

Novel genetic loci underlying human intracranial volume identified through genome-wide association.

  • Adams HH Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
  • Hibar DP Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
  • Chouraki V Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Stein JL Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
  • Nyquist PA Department of Neurology, Department of Anesthesia/Critical Care Medicine, Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA.
  • Rentería ME QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Trompet S Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Arias-Vasquez A Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Seshadri S Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Desrivières S MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Beecham AH Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA.
  • Jahanshad N Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
  • Wittfeld K German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Greifswald, Germany.
  • Van der Lee SJ Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
  • Abramovic L Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands.
  • Alhusaini S Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada.
  • Amin N Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
  • Andersson M Department of Integrative Medical Biology and Umeå center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
  • Arfanakis K Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA.
  • Aribisala BS Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
  • Armstrong NJ Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
  • Athanasiu L NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Axelsson T Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Beiser A Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Bernard M Hospital for Sick Children, University of Toronto, Toronto, Canada.
  • Bis JC Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Blanken LM Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Blanton SH Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA.
  • Bohlken MM Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands.
  • Boks MP Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands.
  • Bralten J Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Brickman AM Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, USA.
  • Carmichael O Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
  • Chakravarty MM Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada.
  • Chauhan G INSERM Unit U1219, University of Bordeaux, France.
  • Chen Q Lieber Institute for Brain Development, Baltimore, Maryland, USA.
  • Ching CR Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
  • Cuellar-Partida G QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Braber AD Biological Psychology, Neuroscience Campus Amsterdam, Vrije Universiteit University and Vrije Universiteit Medical Center, Amsterdam, the Netherlands.
  • Doan NT NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Ehrlich S Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Germany.
  • Filippi I NSERM Unit 1000 ″Neuroimaging and Psychiatry″, University Paris Sud, University Paris Descartes, Paris, France.
  • Ge T Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, North Carolina, USA.
  • Giddaluru S NORMENT - KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Norway.
  • Goldman AL Lieber Institute for Brain Development, Baltimore, Maryland, USA.
  • Gottesman RF Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Greven CU Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Grimm O Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.
  • Griswold ME Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • Guadalupe T Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.
  • Hass J Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Dresden, Germany.
  • Haukvik UK NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Hilal S Department of Pharmacology, National University of Singapore, Singapore.
  • Hofer E Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Austria, Graz, Austria.
  • Hoehn D Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
  • Holmes AJ Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA.
  • Hoogman M Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Janowitz D Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany.
  • Jia T MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Kasperaviciute D UCL Institute of Neurology, London, United Kingdom and Epilepsy Society, Bucks, UK.
  • Kim S Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Klein M Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Kraemer B Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
  • Lee PH Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA.
  • Liao J Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Liewald DC Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.
  • Lopez LM Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.
  • Luciano M Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.
  • Macare C MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Marquand A Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Matarin M UCL Institute of Neurology, London, United Kingdom and Epilepsy Society, Bucks, UK.
  • Mather KA Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
  • Mattheisen M Department of Biomedicine, Aarhus University, Aarhus, Denmark.
  • Mazoyer B UMR5296 University of Bordeaux, CNRS, CEA, Bordeaux, France.
  • McKay DR Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
  • McWhirter R Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
  • Milaneschi Y Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands.
  • Mirza-Schreiber N Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
  • Muetzel RL Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Maniega SM Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
  • Nho K Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Nugent AC Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.
  • Loohuis LM Center for Neurobehavioral Genetics, University of California, Los Angeles, California, USA.
  • Oosterlaan J Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, the Netherlands.
  • Papmeyer M Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.
  • Pappa I Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Pirpamer L Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Austria, Graz, Austria.
  • Pudas S Department of Integrative Medical Biology and Umeå center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
  • Pütz B Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
  • Rajan KB Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
  • Ramasamy A Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
  • Richards JS Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Risacher SL Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Roiz-Santiañez R Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
  • Rommelse N Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Rose EJ Psychosis Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin.
  • Royle NA Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
  • Rundek T Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA.
  • Sämann PG Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
  • Satizabal CL Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Schmaal L Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, Australia.
  • Schork AJ Multimodal Imaging Laboratory, Department of Neurosciences, University of California, San Diego, USA.
  • Shen L Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Shin J Hospital for Sick Children, University of Toronto, Toronto, Canada.
  • Shumskaya E Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Smith AV Icelandic Heart Association, Kopavogur, Iceland.
  • Sprooten E Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
  • Strike LT QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Teumer A Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  • Thomson R School of Computing Engineering and Mathematics, Western Sydney University, Parramatta, Australia.
  • Tordesillas-Gutierrez D CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, Spain.
  • Toro R Institut Pasteur, Paris, France.
  • Trabzuni D Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
  • Vaidya D GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Van der Grond J Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Van der Meer D Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Van Donkelaar MM Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Van Eijk KR Brain Center Rudolf Magnus, Human Neurogenetics Unit, UMC Utrecht, Utrecht, the Netherlands.
  • Van Erp TG Department of Psychiatry and Human Behavior, University of California-Irvine, Irvine, California, USA.
  • Van Rooij D Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Walton E Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Dresden, Germany.
  • Westlye LT NORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Whelan CD Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
  • Windham BG Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • Winkler AM Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
  • Woldehawariat G Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.
  • Wolf C University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wuerzburg, Germany.
  • Wolfers T Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Xu B MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Yanek LR GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Yang J Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
  • Zijdenbos A Biospective Inc, Montreal, Quebec, Canada, Montréal, Québec, Canada.
  • Zwiers MP Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Agartz I NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Aggarwal NT Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
  • Almasy L South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA.
  • Ames D National Ageing Research Institute, Royal Melbourne Hospital, Melbourne, Australia.
  • Amouyel P Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Lille, France.
  • Andreassen OA NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Arepalli S Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
  • Assareh AA Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
  • Barral S Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, USA.
  • Bastin ME Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
  • Becker DM GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Becker JT Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Bennett DA Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
  • Blangero J South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA.
  • van Bokhoven H Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Boomsma DI Biological Psychology, Neuroscience Campus Amsterdam, Vrije Universiteit University and Vrije Universiteit Medical Center, Amsterdam, the Netherlands.
  • Brodaty H Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
  • Brouwer RM Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands.
  • Brunner HG Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Buckner RL Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA.
  • Buitelaar JK Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Bulayeva KB Department of Evolution and Genetics, Dagestan State University, Makhachkala, Dagestan, Russia.
  • Cahn W Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands.
  • Calhoun VD The Mind Research Network and LBERI, Albuquerque, New Mexico, USA.
  • Cannon DM Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.
  • Cavalleri GL The Royal College of Surgeons in Ireland, Dublin 2, Ireland.
  • Chen C Department of Pharmacology, National University of Singapore, Singapore.
  • Cheng CY Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Cichon S Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Cookson MR Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
  • Corvin A Psychosis Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin.
  • Crespo-Facorro B Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
  • Curran JE South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA.
  • Czisch M Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
  • Dale AM Center for Multimodal Imaging and Genetics, University of California, San Diego, California, USA.
  • Davies GE Avera Institute for Human Genetics, Sioux Falls, South Dakota, USA.
  • De Geus EJ Biological Psychology, Neuroscience Campus Amsterdam, Vrije Universiteit University and Vrije Universiteit Medical Center, Amsterdam, the Netherlands.
  • De Jager PL Harvard Medical School, Boston, Massachusetts, USA.
  • de Zubicaray GI Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia.
  • Delanty N The Royal College of Surgeons in Ireland, Dublin 2, Ireland.
  • Depondt C Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium.
  • DeStefano AL Framingham Heart Study, Framingham, Massachusetts, USA.
  • Dillman A Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
  • Djurovic S NORMENT - KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Norway.
  • Donohoe G Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition and Genomics Centre (NICOG) and NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway, Ireland.
  • Drevets WC Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.
  • Duggirala R South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA.
  • Dyer TD South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA.
  • Erk S Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin, Germany.
  • Espeseth T NORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Evans DA Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
  • Fedko IO Biological Psychology, Neuroscience Campus Amsterdam, Vrije Universiteit University and Vrije Universiteit Medical Center, Amsterdam, the Netherlands.
  • Fernández G Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Ferrucci L Intramural Research Program of the National Institute on Aging, Baltimore, Maryland, USA.
  • Fisher SE Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Fleischman DA Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
  • Ford I Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK.
  • Foroud TM Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Fox PT University of Texas Health Science Center, San Antonio, Texas, USA.
  • Francks C Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Fukunaga M Division of Cerebral Integration, National Institute for Physiological Sciences, Aichi, Japan.
  • Gibbs JR Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
  • Glahn DC Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
  • Gollub RL Department of Psychiatry, Massachusetts General Hospital, Boston, Masschusetts, USA.
  • Göring HH South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine Brownsville/Edinburg/San Antonio, Texas, USA.
  • Grabe HJ Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany.
  • Green RC Harvard Medical School, Boston, Massachusetts, USA.
  • Gruber O Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
  • Gudnason V Icelandic Heart Association, Kopavogur, Iceland.
  • Guelfi S Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
  • Hansell NK QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Hardy J Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
  • Hartman CA Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Hashimoto R Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Hegenscheid K Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
  • Heinz A Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin, Germany.
  • Le Hellard S NORMENT - KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Norway.
  • Hernandez DG Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
  • Heslenfeld DJ Department of Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
  • Ho BC Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA.
  • Hoekstra PJ Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Hoffmann W German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Greifswald, Germany.
  • Hofman A Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
  • Holsboer F Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
  • Homuth G Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
  • Hosten N Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
  • Hottenga JJ Biological Psychology, Neuroscience Campus Amsterdam, Vrije Universiteit University and Vrije Universiteit Medical Center, Amsterdam, the Netherlands.
  • Hulshoff Pol HE Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands.
  • Ikeda M Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
  • Ikram MK Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
  • Jack CR Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Jenkinson M FMRIB Centre, University of Oxford, Oxford, UK.
  • Johnson R NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School, Baltimore, Maryland, USA.
  • Jönsson EG NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Jukema JW Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Kahn RS Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands.
  • Kanai R School of Psychology, University of Sussex, Brighton, UK.
  • Kloszewska I Medical University of Lodz, Lodz, Poland.
  • Knopman DS Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Kochunov P Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Kwok JB Neuroscience Research Australia, Sydney, Australia.
  • Lawrie SM Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.
  • Lemaître H NSERM Unit 1000 ″Neuroimaging and Psychiatry″, University Paris Sud, University Paris Descartes, Paris, France.
  • Liu X Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.
  • Longo DL Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
  • Longstreth WT Department of Neurology, University of Washington, Seattle, Washington, USA.
  • Lopez OL Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Lovestone S Department of Psychiatry, University of Oxford, Oxford, UK.
  • Martinez O Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, California, USA.
  • Martinot JL NSERM Unit 1000 ″Neuroimaging and Psychiatry″, University Paris Sud, University Paris Descartes, Paris, France.
  • Mattay VS Lieber Institute for Brain Development, Baltimore, Maryland, USA.
  • McDonald C Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
  • McIntosh AM Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.
  • McMahon KL Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
  • McMahon FJ Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA.
  • Mecocci P Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
  • Melle I NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Meyer-Lindenberg A Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.
  • Mohnke S Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin, Germany.
  • Montgomery GW QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Morris DW Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition and Genomics Centre (NICOG) and NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway, Ireland.
  • Mosley TH Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • Mühleisen TW Centre for Neuroimaging and Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
  • Müller-Myhsok B Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
  • Nalls MA Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
  • Nauck M Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
  • Nichols TE FMRIB Centre, University of Oxford, Oxford, UK.
  • Niessen WJ Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.
  • Nöthen MM Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Nyberg L Department of Integrative Medical Biology and Umeå center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
  • Ohi K Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Olvera RL University of Texas Health Science Center, San Antonio, Texas, USA.
  • Ophoff RA Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht, the Netherlands.
  • Pandolfo M Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium.
  • Paus T Rotman Research Institute, University of Toronto, Toronto, Canada.
  • Pausova Z Hospital for Sick Children, University of Toronto, Toronto, Canada.
  • Penninx BW Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.
  • Pike GB Department of Radiology, University of Calgary, Calgary, Canada.
  • Potkin SG Department of Psychiatry and Human Behavior, University of California-Irvine, Irvine, California, USA.
  • Psaty BM Department of Epidemiology, University of Washington, Seattle, Washington, USA.
  • Reppermund S Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
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  • 2016-11-08
Published in:
  • Nature neuroscience. - 2016
English Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits.
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