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Hijacking of host cell IKK signalosomes by the transforming parasite Theileria.
Journal article

Hijacking of host cell IKK signalosomes by the transforming parasite Theileria.

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  • 2002-11-02
Published in:
  • Science (New York, N.Y.). - 2002
Active Transport, Cell Nucleus
Animals
Antiprotozoal Agents
Apoptosis
Cattle
Cell Cycle
Cell Division
Cell Line, Transformed
Cell Nucleus
Down-Regulation
I-kappa B Kinase
I-kappa B Proteins
Leukocytes
Microscopy, Confocal
NF-kappa B
Naphthoquinones
Phosphorylation
Protein-Serine-Threonine Kinases
Signal Transduction
Theileria
English Parasites have evolved a plethora of mechanisms to ensure their propagation and evade antagonistic host responses. The intracellular protozoan parasite Theileria is the only eukaryote known to induce uncontrolled host cell proliferation. Survival of Theileria-transformed leukocytes depends strictly on constitutive nuclear factor kappa B (NF-kappaB) activity. We found that this was mediated by recruitment of the multisubunit IkappaB kinase (IKK) into large, activated foci on the parasite surface. IKK signalosome assembly was specific for the transforming schizont stage of the parasite and was down-regulated upon differentiation into the nontransforming merozoite stage. Our findings provide insights into IKK activation and how pathogens subvert host-cell signaling pathways.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/192129
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