Journal article
PNA-encoded chemical libraries.
- Zambaldo C Department of Organic Chemistry, NCCR Chemical Biology, University of Geneva, 30 quai Ernest Ansermet, Geneva, Switzerland.
- Barluenga S Department of Organic Chemistry, NCCR Chemical Biology, University of Geneva, 30 quai Ernest Ansermet, Geneva, Switzerland.
- Winssinger N Department of Organic Chemistry, NCCR Chemical Biology, University of Geneva, 30 quai Ernest Ansermet, Geneva, Switzerland. Electronic address: nicolas.winssinger@unige.com.
- 2015-01-27
Published in:
- Current opinion in chemical biology. - 2015
Combinatorial Chemistry Techniques
Drug Discovery
Fluorescent Dyes
Gene Library
Glycoconjugates
HSP70 Heat-Shock Proteins
Heterocyclic Compounds
Lectins
Ligands
Peptide Library
Peptide Nucleic Acids
Small Molecule Libraries
Solid-Phase Synthesis Techniques
English
Peptide nucleic acid (PNA)-encoded chemical libraries along with DNA-encoded libraries have provided a powerful new paradigm for library synthesis and ligand discovery. PNA-encoding stands out for its compatibility with standard solid phase synthesis and the technology has been used to prepare libraries of peptides, heterocycles and glycoconjugates. Different screening formats have now been reported including selection-based and microarray-based methods that have yielded specific ligands against diverse target classes including membrane receptors, lectins and challenging targets such as Hsp70.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.cbpa.2015.01.005
- PMID 25621730
- Persistent URL
- https://sonar.ch/global/documents/192230
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