Journal article
Dopaminergic denervation is not necessary to induce gait disorders in atypical parkinsonian syndrome.
- Allali G Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals and University of Geneva, Switzerland; Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA. Electronic address: gilles.allali@hcuge.ch.
- Garibotto V Division of Nuclear Medicine and Molecular Imaging, Department of Medical Imaging and Information Sciences, Geneva University Hospitals and University of Geneva, Switzerland. Electronic address: valentina.garibotto@hcuge.ch.
- Mainta IC Division of Nuclear Medicine and Molecular Imaging, Department of Medical Imaging and Information Sciences, Geneva University Hospitals and University of Geneva, Switzerland. Electronic address: isminicharis.mainta@hcuge.ch.
- Armand S Willy Taillard Laboratory of Kinesiology, Geneva University Hospitals and University of Geneva, Switzerland. Electronic address: stephane.armand@hcuge.ch.
- Camicioli R Division of Neurology, University of Alberta, Edmonton, Canada. Electronic address: richard.camicioli@ualberta.ca.
- Ratib O Division of Nuclear Medicine and Molecular Imaging, Department of Medical Imaging and Information Sciences, Geneva University Hospitals and University of Geneva, Switzerland. Electronic address: osman.ratib@hcuge.ch.
- Zaidi H Division of Nuclear Medicine and Molecular Imaging, Department of Medical Imaging and Information Sciences, Geneva University Hospitals and University of Geneva, Switzerland. Electronic address: habib.zaidi@hcuge.ch.
- Herrmann FR Department of Internal Medicine, Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Switzerland. Electronic address: francois.herrmann@hcuge.ch.
- Assal F Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals and University of Geneva, Switzerland. Electronic address: frederic.assal@hcuge.ch.
- 2015-03-17
Published in:
- Journal of the neurological sciences. - 2015
Dual task
Gait disorders
Neuroimaging
Nigrostriatal pathways
Parkinsonian syndromes
[(123)I]FP-CIT SPECT
Aged
Aged, 80 and over
Cross-Sectional Studies
Dopaminergic Neurons
Female
Gait
Humans
Male
Middle Aged
Neostriatum
Parkinsonian Disorders
Substantia Nigra
Tomography, Emission-Computed, Single-Photon
English
BACKGROUND
Gait impairment is common in parkinsonian syndromes but not specific to striatonigral dysfunction. The relationship between the dopaminergic system and gait parameters is poorly understood. This cross-sectional study aimed to determine if gait measures are related to the striatal dopamine transporters distribution using [(123)I]FP-CIT SPECT in patients with parkinsonian syndromes.
MATERIALS AND METHODS
Twenty-four patients with gait impairment and parkinsonian syndromes without Parkinson's disease (mean age: 73.6±8.2years) were included in this study. Gait analysis during single- and dual-task condition (walking and backwards counting) and [(123)I]FP-CIT SPECT were performed within 3months of each other. Patients were visually categorized as having normal (n=14) or abnormal (n=10) [(123)I]FP-CIT SPECT. In addition, a volume-of-interest-based analysis of uptake ratios (caudate and putamen) relative to the occipital cortex and a voxelwise analysis using SPM8 were also performed.
RESULTS
Patients with parkinsonian syndromes and abnormal [(123)I]FP-CIT SPECT did not significantly differ in terms of spatiotemporal gait parameters from those with normal [(123)I]FP-CIT SPECT. Moreover, after correction for multiple comparisons, we did not observe any association between regional uptake ratio and spatiotemporal gait parameters for single and dual tasking. Finally, none of these parameters showed a significant association with voxelwise [(123)I]FP-CIT uptake.
CONCLUSIONS
Dopaminergic denervation, as measured by [(123)I]FP-CIT SPECT, is not necessary to induce alterations of spatiotemporal gait parameters during single and dual task in patients presenting with atypical parkinsonian syndromes.
Gait impairment is common in parkinsonian syndromes but not specific to striatonigral dysfunction. The relationship between the dopaminergic system and gait parameters is poorly understood. This cross-sectional study aimed to determine if gait measures are related to the striatal dopamine transporters distribution using [(123)I]FP-CIT SPECT in patients with parkinsonian syndromes.
MATERIALS AND METHODS
Twenty-four patients with gait impairment and parkinsonian syndromes without Parkinson's disease (mean age: 73.6±8.2years) were included in this study. Gait analysis during single- and dual-task condition (walking and backwards counting) and [(123)I]FP-CIT SPECT were performed within 3months of each other. Patients were visually categorized as having normal (n=14) or abnormal (n=10) [(123)I]FP-CIT SPECT. In addition, a volume-of-interest-based analysis of uptake ratios (caudate and putamen) relative to the occipital cortex and a voxelwise analysis using SPM8 were also performed.
RESULTS
Patients with parkinsonian syndromes and abnormal [(123)I]FP-CIT SPECT did not significantly differ in terms of spatiotemporal gait parameters from those with normal [(123)I]FP-CIT SPECT. Moreover, after correction for multiple comparisons, we did not observe any association between regional uptake ratio and spatiotemporal gait parameters for single and dual tasking. Finally, none of these parameters showed a significant association with voxelwise [(123)I]FP-CIT uptake.
CONCLUSIONS
Dopaminergic denervation, as measured by [(123)I]FP-CIT SPECT, is not necessary to induce alterations of spatiotemporal gait parameters during single and dual task in patients presenting with atypical parkinsonian syndromes.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.jns.2015.02.051
- PMID 25772188
- Persistent URL
- https://sonar.ch/global/documents/192279
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