Self-sampling to improve cervical cancer screening coverage in Switzerland: a randomised controlled trial.
- Viviano M Gynecology Division, Department of Obstetrics and Gynecology, Geneva University Hospitals, Boulevard de la Cluse 30, Geneva, 1205, Switzerland.
- Catarino R Gynecology Division, Department of Obstetrics and Gynecology, Geneva University Hospitals, Boulevard de la Cluse 30, Geneva, 1205, Switzerland.
- Jeannot E Institute of Global Health-Faculty of Medicine, Chemin de Mines 9, Geneva 1202, Switzerland.
- Boulvain M Gynecology Division, Department of Obstetrics and Gynecology, Geneva University Hospitals, Boulevard de la Cluse 30, Geneva, 1205, Switzerland.
- Malinverno MU Gynecology Division, Department of Obstetrics and Gynecology, Geneva University Hospitals, Boulevard de la Cluse 30, Geneva, 1205, Switzerland.
- Vassilakos P Geneva Foundation for Medical Education and Research, Route de Ferney 150, Geneva 1211, Switzerland.
- Petignat P Gynecology Division, Department of Obstetrics and Gynecology, Geneva University Hospitals, Boulevard de la Cluse 30, Geneva, 1205, Switzerland.
- 2017-04-21
Published in:
- British journal of cancer. - 2017
Adult
Atypical Squamous Cells of the Cervix
Cervical Intraepithelial Neoplasia
Colposcopy
Early Detection of Cancer
Female
Humans
Middle Aged
Papillomavirus Infections
Patient Acceptance of Health Care
Self Care
Specimen Handling
Switzerland
Triage
Uterine Cervical Neoplasms
English
BACKGROUND
The aim of this study is to evaluate whether self-sampling can increase screening attendance of women who do not attend regular screening in Switzerland.
METHODS
Participants were proactively recruited in Geneva between September 2011 and November 2015. Women (25-69 years) who had not undergone CC screening in the last 3 years were considered eligible. Through a 1 : 1 ratio randomisation, enrolled participants were invited to either undergo liquid-based cytology, which was performed by a health-care provider (control group, CG) or to take a self-sample for HPV-testing, which was mailed to their home (intervention group, IG).
RESULTS
A total of 331 and 336 women were randomised in the CG and in the IG, respectively. Overall, 7.3% (95% CI: 4.9-10.6) women in the CG and 5.7% (95% CI: 3.6-8.7) women in the IG did not undergo the initial screening (P=0.400). There were 1.95% (95% CI: 0.8-4.3) women in the CG and 5.05% (95% CI: 3.1-8.1) women in the IG with a positive screen who did not attend triage and colposcopy (P=0.036).
CONCLUSIONS
The participation in CC screening in women offered self-sampling was not higher than among those offered specimen collection by a clinician. Compliance with further follow-up for women with a positive HPV test on the self-sample requires further attention.
The aim of this study is to evaluate whether self-sampling can increase screening attendance of women who do not attend regular screening in Switzerland.
METHODS
Participants were proactively recruited in Geneva between September 2011 and November 2015. Women (25-69 years) who had not undergone CC screening in the last 3 years were considered eligible. Through a 1 : 1 ratio randomisation, enrolled participants were invited to either undergo liquid-based cytology, which was performed by a health-care provider (control group, CG) or to take a self-sample for HPV-testing, which was mailed to their home (intervention group, IG).
RESULTS
A total of 331 and 336 women were randomised in the CG and in the IG, respectively. Overall, 7.3% (95% CI: 4.9-10.6) women in the CG and 5.7% (95% CI: 3.6-8.7) women in the IG did not undergo the initial screening (P=0.400). There were 1.95% (95% CI: 0.8-4.3) women in the CG and 5.05% (95% CI: 3.1-8.1) women in the IG with a positive screen who did not attend triage and colposcopy (P=0.036).
CONCLUSIONS
The participation in CC screening in women offered self-sampling was not higher than among those offered specimen collection by a clinician. Compliance with further follow-up for women with a positive HPV test on the self-sample requires further attention.
- Language
-
- English
- Open access status
- hybrid
- Identifiers
-
- DOI 10.1038/bjc.2017.111
- PMID 28427086
- Persistent URL
- https://sonar.ch/global/documents/232773
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