![[Chronic meningococcemia and IgA deficiency in an adolescent].](/static/images/no-image.png)
Journal article
[Chronic meningococcemia and IgA deficiency in an adolescent].
- Farron F Service de pédiatrie, centre hospitalier universitaire Vaudois, Lausanne, Suisse.
- Cheseaux JJ
- Pelet B
- 1996-02-01
Published in:
- Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. - 1996
Adolescent
Ceftriaxone
Cephalosporins
Chronic Disease
Humans
IgA Deficiency
Male
Meningococcal Infections
Penicillins
English
BACKGROUND
Chronic meningococcemia, defined as a meningococcal septicemia without meningeal symptoms with persistence of fever for at least one week prior to any antibiotics, is uncommon. Its pathophysiology remains unclear and a defect in host immunity has been suggested.
CASE REPORT
A 15 year-old adolescent was examined because he suffered from fever for 6 days, headache, arthralgias. A disseminated erythema led to consider the diagnosis of vascularitis that was confirmed by skin biopsy. At day 9, blood culture yielded Neisseria meningitis group B that was confirmed by a second blood culture; the CSF was normal and sterile. The patient was given ceftriaxone plus penicillin for 14 days and completely cured. A detailed analysis of the complement system was negative but the patient was found to be deficient in IgA.
CONCLUSION
This is the first reported case in which chronic meningococcemia is associated with complete IgA deficiency.
Chronic meningococcemia, defined as a meningococcal septicemia without meningeal symptoms with persistence of fever for at least one week prior to any antibiotics, is uncommon. Its pathophysiology remains unclear and a defect in host immunity has been suggested.
CASE REPORT
A 15 year-old adolescent was examined because he suffered from fever for 6 days, headache, arthralgias. A disseminated erythema led to consider the diagnosis of vascularitis that was confirmed by skin biopsy. At day 9, blood culture yielded Neisseria meningitis group B that was confirmed by a second blood culture; the CSF was normal and sterile. The patient was given ceftriaxone plus penicillin for 14 days and completely cured. A detailed analysis of the complement system was negative but the patient was found to be deficient in IgA.
CONCLUSION
This is the first reported case in which chronic meningococcemia is associated with complete IgA deficiency.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/0929-693x(96)85068-8
- PMID 8785537
- Persistent URL
- https://sonar.ch/global/documents/277679
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